Malaria, along with many other mosquito-borne illnesses, can be present within the Okavango and thus preventive measures are imperative. It is important to note that the occurrence of mosquito-borne illnesses is much higher in the wet season the same is true for any tropical location.
The Okavango Delta is generally considered safe for travelers, although as with any part of Africa necessary precautions should always be taken. The Okavango is home to many potentially dangerous animals including, but not limited to, the Nile Crocodile, Lion and Hippo but attacks on tourists are virtually unheard of, it is best to closely follow the instructions of your guide at all times.